33 articles - From Friday Sep 30 2022 to Friday Oct 07 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
| Arthritis Care Res (Hoboken) |
Evaluation of Financial and Non-financial Conflicts of Interest and Quality of Evidence underlying Psoriatic Arthritis Clinical Practice Guidelines-Analysis of Personal Payments from Pharmaceutical Companies and Authors' Self-citation Rate in Japan and the United States. More rigorous cross-checking of information disclosed by pharmaceutical companies and self-reported by physicians, and more stringent and transparent COI policies are necessary. |
meta-analyses and systematic reviews
RCT, clinical trials, retrospective studies, etc…
| Ann Rheum Dis |
Belimumab use during pregnancy: a summary of birth defects and pregnancy loss from belimumab clinical trials, a pregnancy registry and postmarketing reports. Observations reported here add to limited data published on pregnancy outcomes following belimumab exposure. Low numbers of exposed pregnancies, presence of confounding factors/other biases, and incomplete information preclude informed recommendations regarding risk of birth defects and pregnancy loss with belimumab use. |
PU.1 promotes development of rheumatoid arthritis via repressing FLT3 in macrophages and fibroblast-like synoviocytes. These results support the role of PU.1 in RA and may have therapeutic implications by directly repressing FLT3. Therefore, targeting PU.1 might be a potential therapeutic approach for RA. |
Risk of major adverse cardiovascular and venous thromboembolism events in patients with rheumatoid arthritis exposed to JAK inhibitors versus adalimumab: a nationwide cohort study. This study provides reassuring data regarding the risks of MACEs and VTEs in patients initiating a JAKi versus adalimumab, including patients at high risk of cardiovascular diseases. |
Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 in osteoarthritis. Synovial fibroblasts assume distinct functional identities during PTOA in mice, and Prg4 hi lining fibroblasts secrete Rspo2 that may drive pathological joint crosstalk after injury. |
| Arthritis Care Res (Hoboken) |
Hurried Communication and Low Patient Self-Efficacy are Associated with Persistent Nonadherence to Lupus Medications. Potential avenues to improve medication adherence include optimizing patient-provider communication, specifically avoiding difficult vocabulary and fast speech, and enhancing patient self-efficacy, particularly among younger Black patients with lower income who are at higher risk for nonadherence. |
The Road to Total Knee Replacement - Utilisation of Knee Surgeries up to 10 There are comparable trends in the use of knee surgery in the years preceding TKR across England and Sweden. Of note, meniscal surgeries remain common, even within the year prior to TKR, highlighting that these patients may experience low-value care. Careful consideration of knee surgery in those with late-stage disease is required. |
| Arthritis Res Ther |
Deep learning-based automatic-bone-destruction-evaluation system using contextual information from other joints. The proposed system was useful. All the target joints were detected with high accuracy. The classification model that compared the same contralateral joint showed better performance than the orthopedic surgeons regarding erosion. |
Dorso-ventral osteophytes of interphalangeal joints correlate with cartilage damage and synovial inflammation in hand osteoarthritis: a histological/radiographical study. dvOPs are associated with increasing structural alterations in DIP and PIP joints and can be seen as markers of advanced joint damage. Detecting dvOPs can facilitate the diagnosis process and improve damage estimation in HOA. |
| Rheumatology (Oxford) |
Association between beverage consumption and risk of rheumatoid arthritis: a prospective study from the French E3N Cohort. In a large cohort of women, tea, alcohol, and sugar-sweetened soft drinks consumption was not associated with RA risk, whereas consumptions of coffee (especially caffeinated coffee), and artificially-sweetened soft drinks were associated with higher RA risk, particularly among never-smokers. If further confirmed, these results could lead to novel mechanistic hypotheses and to simple prevention measures. |
Baseline knee extension may be associated with volumetric cartilage loss in the anterolateral tibia: data from the Osteoarthritis Initiative. While causation cannot be determined in this study, limitation in knee extension was statistically associated with the percentage denuded bone in the anterolateral tibia. These novel data support that maintaining range of motion over the entire joint surface may help preserve articular cartilage health. |
Comparison of healthcare utilisation, costs and health-related quality of life across the subgroups defined by the Keele STarT MSK Tool. This study demonstrates that subgroups of people with different risk of poor musculoskeletal pain outcomes also have different levels of healthcare utilization, healthcare costs, health-related quality of life and work outcomes. The findings show that the STarT MSK tool not only identifies those at risk of a poorer outcome, but also those who will have more healthcare visits and incur higher costs. |
Cutaneous vasculitis occurring in the setting of systemic lupus erythematosus: a multicenter cohort study. SLE-related vasculitis seems very rare and other causes of vasculitis should be ruled out before considering this diagnosis. Moreover, in more than half of patients, CV was not associated with another sign of active SLE. |
Determination of four homogeneous subgroups of patients with antiphospholipid syndrome: a cluster analysis based on 509 cases. Our study applied an unsupervised clustering method to distinguish four homogeneous APS patient subgroups that were predominantly venous; arterial; associated with SLE or another autoimmune disease; and arterial microthrombotic. Heterogeneous pathophysiological mechanisms may explain these findings. |
Improved Sensitivity of Skin Pathergy Test with Polysaccharide Pneumococcal Vaccine Antigens in the Diagnosis of Behçet Disease. SPT induced by 20G needle-prick and PS-23 antigens was shown to be a promising tool for the diagnosis of BD owing to its improved sensitivity compared with the standard applications. |
Non-Trough adalimumab and certolizumab drug levels associated with a therapeutic EULAR response in adherent patients with rheumatoid arthritis. In fully adherent patients, higher SDLs are detected in good responders suggesting that interventions to improve SDLs such as encouraging adherence could improve treatment response. 3-month non-trough SDL cut-offs of 7·5mg/l for Adalimumab and 26·0mg/l for Certolizumab may be useful in clinical practice. |
Novel mutation and expanding phenotype in IRF2BP2 deficiency. The identified loss-of-function variant in IRF2BP2 severely impairs B-cell development, T-cell homeostasis and may be associated with colitis and RA. Our results provide further evidence for association of IRF2BP2 with CVID and contribute to understanding the underlying pathomechanisms. |
Revisiting idiopathic eosinophilic myositis: toward a clinical-pathological continuum from the muscle to the fascia and skin. The analysis of IEM and EF patient characteristics delineates 4 subgroups (FEM, DEM, EMF, and EF) in terms of clinical, laboratory, imaging, pathological, and outcome specificities and proposes an adapted diagnostic and care management approach. |
Systemic Sclerosis Associated Interstitial Lung Disease: A Conceptual Framework for Subclinical, Clinical, and Progressive Disease. Using our proposed conceptual framework, international experts were able to achieve a consensus on classifying SSc-ILD patients along the dimensions of disease severity, risk of progression, and progression over time. Experts rely on similar items when classifying disease severity and progression a combination of spirometry and gas exchange and quantitative HRCT. |
Trust in the attending rheumatologist, health-related hope, and medication adherence among Japanese systemic lupus erythematosus patients. This study demonstrated that patients' health-related hope and trust in their rheumatologist were both associated with better medication adherence in SLE. |
Type H vessels-a bridge connecting subchondral bone remodelling and articular cartilage degeneration in osteoarthritis development. In future, the pathogenesis of KOA could be further clarified by the bridge of type H vessels and the design of new disease-modifying osteoarthritis drugs (DMOADs). However, further experiments are needed to determine the upstream signals regulating type H vessel formation in osteoarthritic subchondral bone. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Ann Rheum Dis |
Clinical trials in systemic lupus erythematosus: the dilemma-Why have phase III trials failed to confirm the promising results of phase II trials? In this review, we will focus on phase II and III trials carried out with epratuzumab (anti CD22), baricitinib (Janus kinases inhibitor), rigerimod (P140 peptide) and ustekinumab (IL-12 and IL-23 inhibitor) and consider the reasons for their ultimate failure to 'make the grade'. Likewise, we will try to explain the possible reasons that can influence why good results may be obtained in phase II trials and lead to undue optimism. |
| Arthritis Care Res (Hoboken) |
Equity considerations in COVID-19 vaccination studies of individuals with autoimmune inflammatory rheumatic diseases. Sex and age were the most frequently considered PROGRESS-Plus factors in studies of COVID-19 vaccination in individuals with AIRDs. The generalizability of evidence to populations experiencing inequities is uncertain. Future COVID-19 vaccine studies should report participant characteristics in more detail to inform guideline recommendations. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Arthritis Rheumatol |
| Rheumatology (Oxford) |